Low human exposure to styrene in relation to chromosome breaks, gaps and sister chromatid exchanges
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چکیده
منابع مشابه
Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.
Sister chromatid exchanges, which may reflect chromosome repair in response to certain types of DNA damage, provide a means of investigating the increased chromosome fragility characteristic of Fanconi's anemia. By a recently developed technique using 33258 Hoechst and 5-bromodeoxyuridine, it was observed that the baseline frequency of sister chromatid exchanges in phytohemagglutinin-stimulated...
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Styrene induces sister chromatid exchanges (SCEs) in human whole-blood lymphocyte cultures without exogenous metabolizing systems, which indicates that styrene is metabolically activated in this in vitro system. Whole-blood lymphocyte cultures from 11 male donors showed a clear increase in SCEs after a 48-hr treatment with styrene (2 mM) or with the reactive metabolite styrene 7,8-oxide (0.15 m...
متن کاملSister Chromatid Exchanges in Sheep Peripheral Lymphocytes after in Vitro Exposure to Metal· Containing Emission
D i a nov s k}' J .. K. S i v i kova: Sister Chrommid Exchanges ill Sheep Peripheral Lmzplwcytes ajier in \'itro E.ll'oslire to Metal·Containing Emissioll. Acta vet. Bmo 1998.67: 183·188. Industrial pollutants. originated from aluminum processing factory. were tested for induction of sister chromatid exchanges (SCE). Experiments were carried out using sheep peripheral lymphocytes under in vitro...
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The chelating agent, diethylenetriaminepentaacetic acid (DTPA) is a non-registered drug used in the treatment of over-exposure to heavy metals such as iron, zinc and lead (Fahey et al., 1961; Brugsch et al., 1965). DTPA has also been used on a few occasions in the United Kingdom when individuals have inhaled plutonium dust or received contaminated wounds (Schofield and Dolphin, 1974). These pat...
متن کاملSister chromatid exchanges in human lymphocytes after anaesthesia with fluroxene.
The potential mutagenicity of fluroxene was investigated by the sister chromatid exchange (SCE) test using lymphocytes in peripheral blood from patients before and after anaesthesia. Twenty-five female patients, aged 21 -77 yr (median 36.5yr) were anaesthetized for gynaecological operations with fluroxene in nitrous oxide for 60-220 nun (median 110 min). The number of SCE per cell was the same ...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2008
ISSN: 0018-0661
DOI: 10.1111/j.1601-5223.1984.tb00109.x